Xiaoshi Wang's A Novel Heme-Thiolate Peroxygenase AaeAPO and Its PDF

By Xiaoshi Wang

ISBN-10: 3319032356

ISBN-13: 9783319032351

during this thesis, Xiaoshi Wang investigates the functionality and mechanism of a newly found heme-thiolate peroxygenase, AaeAPO. This enzyme category comes from Agrocybe aegerita and is utilized in the conversion of inert hydrocarbons to alcohols. Xiaoshi's paintings specializes in an extracellular P450 enzyme which isn't restricted in its balance and absence of solubility and accordingly is suitable for frequent business use. the writer demonstrates that the peroxygenase catalyzes quite a lot of reactions. often times the writer even describes very tough changes in molecules which are hugely inert. Her specific investigations supply a mechanistic framework for a way the peroxygenase catalyzes this type of huge variety of reactions. a huge spotlight of this thesis is the id of key short-lived intermediates within the catalytic cycle of the peroxygenase, utilizing quick kinetic and spectroscopic tools, in addition to the elucidation of the thermodynamic houses of those high-energy intermediates. This paintings provides new perception into an enormous category of enzymes.

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A Novel Heme-Thiolate Peroxygenase AaeAPO and Its Implications for C-H Activation Chemistry (Springer Theses) by Xiaoshi Wang

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