Download e-book for iPad: Affinity and Efficacy:The Components of Drug-Receptor by Frederick J Ehlert

By Frederick J Ehlert

ISBN-10: 9814322563

ISBN-13: 9789814322560

The interplay of a drug with a receptor generates a code of data having parts of affinity and efficacy. How this data is translated right into a reaction depends upon the original cells, tissue, organ or process during which the receptor is living. This booklet describes how one can research a variety of responses to estimate the affinity and efficacy elements of the preliminary drug–receptor interplay. extra in particular, it describes the best way to degree the affinity and efficacy of gear in the course of the research of unmarried receptor job, the activation country of a inhabitants of receptors, and responses downstream from receptor activation. extra mild is thrown on ligand-gated ion channels and G protein-coupled receptors during this book.

The issues mentioned comprise radioligand binding, estimation of agonist affinity and efficacy, aggressive antagonism, inverse agonism, allosteric agonists and modulators, agonist bias, modulation of pathway selectivity, and the estimation of ligand affinity for lively and inactive receptor states. The average historical past and constitution of ligand-gated ion channels, G proteins, and G protein-coupled receptors also are discussed.

Show description

Read or Download Affinity and Efficacy:The Components of Drug-Receptor Interactions PDF

Similar pharmacology books

Joseph S. Bertino,Angela Kashuba,Joseph D. Ma,Uwe Fuhr,C.'s Pharmacogenomics An Introduction and Clinical Perspective PDF

An entire INTRODUCTORY textual content TO the sector OF PHARMACOGENOMICS the single pharmacogenomics source to add a world writer workforce made from PharmDs, MDs, PhDs and social scientists, Pharmacogenomics deals a necessary, hugely obtainable survey of this dynamic self-discipline. you'll find thorough insurance of all need-to-know subject matters, from person molecules to systemic illnesses, plus an exam of the most recent applied sciences which are consistently reshaping the sphere.

Download e-book for kindle: The Cult of Pharmacology: How America Became the World’s by Richard DeGrandpre

The United States had a extensively diversified courting with medications a century in the past. Drug prohibitions have been few, and whereas alcohol was once thought of a risk, the general public on a regular basis ate up elements which are extensively demonized this present day. Heroin was once advertised by way of Bayer prescription drugs, and marijuana was once to be had as a tincture of hashish offered through Parke Davis and corporate.

Download e-book for kindle: Taschenbuch der Arzneibehandlung: Angewandte Pharmakologie by G. Kuschinsky,Hasso Scholz,Ulrich Schwabe

Haben Sie Fragen zu Arzneimittelauswahl und Therapieführung? Die thirteen. Auflage des Taschenbuchs der Arzneibehandlung bietet zuverlässige Informationen zur genauen Beurteilung der therapeutischen Wirkung der 1. 500 meistverwendeten Arzneimittel. In 24 krankheitsbezogenen Kapiteln werden die Prinzipien der Arzneitherapie auf der foundation von Pathogenese und Symptomatik dargestellt (Teil I).

Download e-book for iPad: Neurotoxicity of Nanomaterials and Nanomedicine by Xinguo Jiang,Huile Gao

Neurotoxicity of Nanomaterials and Nanomedicine provides an outline of the interesting learn in neurotoxicity and nanomaterials. Nanomaterials were greatly utilized in medication, together with analysis probes, drug companies, and embedded fabrics. whereas a few were authorized for scientific use, such a lot nanomaterials are ready to be transferred from lab to medical institution.

Extra resources for Affinity and Efficacy:The Components of Drug-Receptor Interactions

Example text

Download PDF sample

Affinity and Efficacy:The Components of Drug-Receptor Interactions by Frederick J Ehlert

by Ronald

Rated 4.54 of 5 – based on 29 votes